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Microdacyn

Wound Care Solution & Hydrogel

Microdacyn is a completely new technology class & it's important to understand how it works so you can use it to its full potential
 
 Very simply 
 
Microdacyn works by replicating and utilizing similar oxygen based species (hypochlorous acid) that are produced naturally in the bodies infection response and the healing process.
By using theses species to fight infection and help wounds heal we can work with nature in synergy rather than intoxicating the wounds biological environment in crude chemicals.
 

Old Vs New Antiseptics - How They Work

The following is a generalization between the way in which chemical products such as; Povidone Iodine, Chlorhexidine, Hydrogen Peroxide & PHMB function as antimicrobials in wound care in comparison Super-Oxidised Solutions such as Microdacyn.
 

Microdacyn Physical Mechansim

Microdacyn uses Osmotic force to rupture pathogens, not chemical bonding.

Its mechanism is selective to single cells organisms and thus multi-cellular human tissue is not a target for action

 First Action 
Microdacyn® surrounds single-cell microorganisms.
The highly oxidative Microdacyn Solution attacks the cell wall of the microorganisms damaging the biochemical bonds and increasing its permeability.
Since our body’s own cells have the necessary processes to prevent cell damage, they are not destroyed.
Second Action 

The very hypotonic Microdacyn® solution ensures that water increasingly flows into the cells to equalize the osmotic gradient. The increasing internal pressure causes the cells to burst.
 
This purely physical effect ensures a highly effective reduction in pathogen load very quickly.
 
This mechanism does not generate bacterial resistance!

How Effective is Microdacyn?

 

Biofilms & Microdacyn

In much the same way humans cooperate to better our chances of survival, so do bacteria and other pathogens.

 

Given the chance to communicate (quorum sensing), pathogens work together to build a physical 'shield' (polymeric matrix) in defense to the host's immune system which is also very effective at limiting the effectiveness of antibiotics and many commonly used antiseptics

 

BioFilms are not always visually identifiable within a wound but may be deduced by the experienced clinicians as a result of a hindrance to typical wound healing.

 

 

    Below is an example of the effect Microdacyn has on Biofilm that is unique to super-oxidising solutions    

 

 BioFilm Action 
 
  • Microdacyn rapidly penetrates biofilms killing microbes within.
     
  • This effect also disaggregates the biofilm structure making it less adherent and more easily removed
     
  • Finally, Microdacyn physically reduces the biofilm mass as the scaffolding of the matrix is damaged internally and the living microbial colony is eliminated. 
 
Biofilms are present in over 60% of chronic wounds and Microdacyn provides a simple and effective method to manage them quickly.
 BioFilm Kill Example
Below shows fluorescence spectroscopy of a mature Pseudomonas arganosoia biofilm before the addition of Microdacyn
 
Under fluorescence:
living microbes appear Green
Dead microbes appear Red 
 
You can easily see the whole cluster is illuminated bright green indicating a living microbial colony
time = 0
 Comparison
 
Now compare the fluorescence spectroscopy of the same Pseudomonas arganosoia biofilm after the continued exposure to Microdacyn after 10 minutes
 
You can easily see the cluster has been uniformly penetrated whereby the green has turned red indicating the majority of living microbes have now been killed
time = 10
Depiction of the Iodines Antiseptic Mechanisim

Chemical Mechansim

 How they work 
 
The active ingredient binds the cell blocking and disrupting essential cell mechanisms such as efflux pumps and respiratory functions. Without these functions, the cell quickly dies in an unarguably effective process.

However, this chemical interaction has NO ability to differentiate between pathogenic cells and healing tissue cells.
This leads to its attributed cytotoxicity
 
How do they work on Biofilms? 
 
Chemical antimicrobials mechanism of binding to cell structures lead them to bind to biofilms instead of penetrating through them.
 
Even the most advanced chemically moded antimicrobials require hours if not days of continuous wound contact to significantly reduce biofilms.
 

Microdacyn Healing

 
 Non-Irritating | pH Neutral | Non-Cytotoxic 
 
An ideal wound cleanser provides periodic reduction of bacterial contamination and removal of debris without adversely impacting cellular activities vital to the wound healing process
 
Microdacyn breaks the traditional paradigm in weighing up healing disruptions with aggressive infection control.
 
This might seem simple but we have been using very aggressive antiseptics on wounds for a long time and its time limit their use where possible.

The latest revision of the International Wound Infection Institute (IWII 2016) clearly state;

“Use antiseptics at the lowest effective concentration to minimize harm to skin and tissue cells involved in wound healing”

The enormous difference in germicidal potency is due to the fact that HOCl an uncharged species can penetrate microbial cell walls, whereas charged ionic species cannot

 Angiogenesis & Oxygen Supply 
 
Reactive oxygen species are important mediators in the VEGF (Vascular Endothelial Growth Factor) cycle.
 
Microdacyn is documented in more than 10 years of studies to increase the local transcutaneous oxygen pressure (TcPO2) after the wound has been saturated in Microdacyn.
 
By increasing the amount of available oxygen to the wound while healing may reduce the wound time to heal.
In patients that are high-risk such as diabetics, this benefit may be more significant to healing outcomes.​

Clinical Evidence in Venous Leg Ulcers

 

This graph demonstrates the averaged effects of applying Microdacyn to 393 non-insulin dependent diabetics (NIDDM) venous leg ulcers.

 

The oxygenation of the peri-wound is increased significantly within 30 seconds and is partly sustained for up 72 hours.

 

The potential to simultaneously improve the integrity of the healing tissue whilst minimizing the impact of infection is a new concept to topical wound care technologies and is what sets Microdacyn apart from regular chemical antiseptics

 

 

*In patients that actively smoke this effect is negated.

To read the full clinical paper click here

 

 

Effect of comorbidities on the microcirculatory response of peri-wound tissue to Microdacyn exposure.

TccPO2 measures

What does this combination of effects mean for wound healing?

"The addition of Microdacyn to our treatment protocols has provided significant microcirculatory amendment of the damage caused by the presence of comorbidities.

 

Considerable bioburden reductions, via direct antimicrobial effects, as well as prevention of biofilm recurrence, quickly improve tissue conditions within the wounds.

 

Treatment cost reductions are facilitated by the shortened healing times and the reduced need for expensive wound care materials and modalities."

Cheryl M. Bongiovanni,  - PhD, RVT, CWS, FASA, FACCWS

Journal of the American College of Clinical Wound Specialists (2016) 6, 32–7

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